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7 Functional analysis of Krox‐20 in the developing central nervous system
Author(s) -
Charnay P.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80202-4
Subject(s) - citation , library science , computer science
The role of mouse engrailed genes in midhindbrain development Wurst, W. aud Blanquet. V. GSF-Fasd~ungszeotrum. Institut fiir Ceuetik. Obe4whleissheim. Germany. In most vertebrates there are two haneohox-anltaiuiog Engmilad genes. Both genes are expressed liom 8Sdpc in a bad the nemwpithelium which will give rise to the meseooepbalic-metencqhalic region @es-met). To study the L~II ~~sesfenes during tmbryooic development we in both genes by homologous remmbination. Mice homozygons fa a home&ox deletiou (En-ZMM) in the b-2 gene nre viable but have patterning defects in the adult cerebellum. In contravt. mice homozygous fa * hane&3x deletion in the h-1 gene (En-lwM) die at birth sod display a deletion of the caebellum and iuftia mlliculi. Mice carrying hanmygous mutations in both En genes (EnFM; En-FM) display a more severe deletion of the mesmet tissueshown by histology aud various mid-hindbrain makers. These reds suggest that thete is a ftmctioud overlap between the d&y related En-2 zctd En-l genes in midIhdhin development In addtion. in a3mpowd &e homozygous mutants Wnr-l as well as Pax-2 expnmkm is induced hut not maintained suggesting that ~51graiM is necessary fa maintemwe of Wnr-I as well a9 fa Pax-2 expression in mid-hinbraiu development. These observations iudicate that the genetic interactions of the segmeutpdatity genes qyuikdwingless ad goodmy might he amserved from Dnwophila to mammals. TAURINE AND NEURON-GLIA