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Effect of early cortical lesion on the acute model of epilepsy
Author(s) -
Ćulić M.,
Šaponjić J.,
Janković B.,
Peković S.,
Stojilković M.,
Udović S.,
Rakić Lj.
Publication year - 1995
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(95)00021-8
Subject(s) - lesion , epilepsy , cortex (anatomy) , medicine , neuroscience , penicillin , anesthesia , psychology , pathology , biology , antibiotics , microbiology and biotechnology
The experiments were performed in order to investigate the sparing of function following early postnatal cortical lesion in the acute rat model of epilepsy. Sensomotor cortex was unilaterally removed at 9 and 10 days of postnatal age in lesioned animals, while control animals were only sham operated (at the same early stage of life) or non‐operated (before implantation of the electrodes). Seizure activity was recorded by means of electroencephalograms at adult stage of life induced by parenteral administration of penicillin (1 000 000 I.U./kg, i.p.). Our results showed that when the cortical lesion was performed in infancy (on the contrary to the lesion performed in adulthood) there was no prolongation of seizure activity in an acute model of epilepsy.