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The ability to re‐express polysialylated NCAM in soleus muscle after denervation is reduced in aged rats compared to young adult rats
Author(s) -
Olsen Marianne,
Zuber Christian,
Roth Jürgen,
Linnemann Dorte,
Bock Elisabeth
Publication year - 1995
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(95)00003-y
Subject(s) - polysialic acid , neural cell adhesion molecule , reinnervation , denervation , sialic acid , soleus muscle , neurite , chemistry , endocrinology , microbiology and biotechnology , neuroscience , medicine , biology , biochemistry , cell adhesion , skeletal muscle , cell , in vitro
The neural cell‐adhesion molecule, NCAM, contains an unusual homopolymer of sialic acid units, polysialic acid. This carbohydrate seems to be involved in neurite outgrowth, bundling and branching, processes which are important during reinnervation. In aged rats, reinnervation of denervated muscle fibres is incomplete. In this study, age‐related changes in the degree of polysialylation of NCAM re‐expressed after denervation were examined using a monoclonal antibody recognizing polysialic acid and a polyclonal antibody recognizing NCAM. The results show that, after denervation, the degree of polysialylation on NCAM was clearly reduced in rat soleus muscle of aged, compared to young, adult rats. This age‐related change in expression of polysialic acid probably influences the reinnervation process in aged muscle.