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Migration behavior of granule cells on laminin in cerebellar microexplant cultures from early postnatal reeler mutant mice
Author(s) -
Nagata Isao,
Terashima Toshio
Publication year - 1994
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(94)90022-1
Subject(s) - reeler , neuroblast , cerebellum , granule (geology) , precursor cell , cerebellar cortex , granule cell , laminin , biology , microbiology and biotechnology , mutant , neuroscience , cell , neurogenesis , hippocampal formation , dentate gyrus , genetics , reelin , extracellular matrix , paleontology , gene
The behaviors of neuroblasts of granule cell neurons and their precursor cells on a poly‐ l ‐lysine/laminin substratum were examined in cerebellar microexplant cultures from early postnatal reeler mutant and normal mice. The total numbers of migrating neuroblasts and their precursor cells or blast cells derived from the mutant cerebellum were markedly reduced in comparison with their normal counterparts. However, no difference was shown between these two strains in either the numbers of blast cells or neuroblasts that migrated from single explants. In addition, all behaviors examined, such as migration of neuroblasts and the proliferation of blast cells in culture were identical between both genotypes. Thus, behaviors of both granule cells and their precursors in the cerebellar cortex of reeler mutant mouse may be qualitatively identical to those of normal counterparts, but precursors of granule cells in the external germinal layer of the cerebellar cortex may be reduced in the reeler mouse.