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Neural functions of the transforming growth factors β
Author(s) -
Krieglstein Kerstin,
Rufer Matthias,
SuterCrazzolara Clemens,
Unsicker Klaus
Publication year - 1995
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(94)00062-8
Subject(s) - biology , neuroscience , anatomy , library science , computer science
II. The TGF-13 isoforms and their functions in the nervous system 1. TGF-I3s are widely distributed in the developing and adult nervous system 2. TGF-13s control important events in neural development (a) TGF-13s govern early steps in morphogenesis and phenotypic decisions (b) TGF-13s and radial glial cell functions (c) TGF-I3s control proliferation of neural progenitors (d) TGF-13s control neuron survival (e) GF-I3s affect axon growth 3. TGF-I3s orchestrate the responses of the nervous system to lesions (a) TGF-13s co-operate with and determine the actions of other cytokines (b) Expression of TGF-13s is altered in neural lesions and neurodegenerative diseases (c) TGF-13s regulate astroglial cell proliferation and phenotype (d) TGF-13s and the microglial response (e) TGF-13s and the Schwann cell response (f) TGF-13s are potent neuroprotective agents 4. TGF-I3s in the treatment of neurological disorders