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Migration pathways, differentiation and survival of macroglial cells from a xenograft implanted into the thalamus of newborn mice
Author(s) -
Quiro J.,
Colin C.,
Villarroya H.,
Collins P.,
Jacque C.
Publication year - 1993
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(93)90044-e
Subject(s) - internal capsule , corpus callosum , thalamus , neuroscience , biology , parenchyma , anatomy , transplantation , external capsule , inferior colliculus , midbrain , pathology , central nervous system , white matter , medicine , nucleus , magnetic resonance imaging , botany , radiology
Embryonic rabbit corpus callosum transplants were grafted into the thalamus of newborn shiverer mice in order to compare the fates of oligodendroglial and astroglial cells derived from the transplants. Our model allowed the identification of the two populations of macroglial cells. The thalamus was chosen as site of implantation because of its situation at a crossroad of numerous neuronal fascicles. Previous studies, where the dorsal striatum was used as site of implantation, had shown that corpus callosum was one of the favorite routes of migration for both populations of macroglial cells. In the present study special attention was given to the comparison of the migration pathways and areas of settlement of implanted astroglia and oligodendroglia. The internal capsule, the medial lemniscus, the crus cerebri and the thalamic radiations were used by both populations of transplant derived macroglial cells for their migrations through the host parenchyma. They integrated into the host tissue on these routes or further away in areas such as the putamen, the mesencephalon or the colliculi. Signs of degeneration of the implanted astroglia were often observed after 1 month post‐implantation.