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Regulation of the low affinity receptor for nerve growth factor, p75 NGFR , in the olfactory system of neonatal and adult rat
Author(s) -
Turner Christopher P.,
PerezPolo J. Regino
Publication year - 1992
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(92)90025-u
Subject(s) - olfactory bulb , olfactory system , olfactory ensheathing glia , olfactory nerve , biology , nerve growth factor , neuroscience , granule cell , olfactory receptor , receptor , olfactory receptor cell , olfactory epithelium , central nervous system , medicine , endocrinology , microbiology and biotechnology , dentate gyrus , biochemistry
Using MAb192, a monoclonal antibody to the rat low affinity receptor for nerve growth factor (p75 NGFR ), we determined the expression of p75 NGFR in rat neonatal and adult olfactory system. In neonates and adults, we observed discrete p75 NGFR ‐immunoreactivity (p75 NGFR ‐ir) in the glomerular layer of the main olfactory bulb. The intensity and organization of glomerular p75 NGFR ‐ir increased with age. This was in keeping with the general ontogeny of the main olfactory bulb. Generally, granule cells, mitral cells and periglomerular cells of the main olfactory bulb were not specifically stained. However, in early neonates, granule cells close to the lateral olfactory tract exhibited p75 NGFR ‐ir. Additional specific staining was found in the olfactory receptor neurons of neonatal and adult olfactory neuroepithelium, the olfactory fascicles and in the glomeruli of the accessory olfactory bulb. The intensity, but not the organization, of specific staining in the accessory olfactory bulb increased as the animal matured. We believe that p75 NGFR ‐ir in the olfactory system is associated with its unique capacity to regenerate its peripheral input to the main olfactory bulb. The presence of p75 NGFR ‐ir in the accessory olfactory bulb would suggest a broader role for this protein. Here we discuss the implications of these findings with regards to nerve growth factor, other trophic molecules, and their receptors. The data presented provide a foundation for studies involving manipulation of regenerative phenomena while monitoring the expression of neurotrophic factors and their receptors.