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Sprouting by isolated Helisoma neurons: Enhancement by glutamate
Author(s) -
Bulloch A. G. M.,
Hauser G. C.
Publication year - 1990
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(90)90072-a
Subject(s) - glutamate receptor , neurite , sprouting , neurotransmitter , neuroscience , neurotrophic factors , biology , snail , nerve growth factor , neurotrophin , microbiology and biotechnology , central nervous system , chemistry , biochemistry , botany , in vitro , receptor , ecology
We tested glutamate for its ability to modulate neurite outgrowth from isolated neurons of the adult snail, Helisoma trivolvis . Although glutamate did not induce neunte outgrowth from neurons maintained in defined medium, nevertheless it showed a dose‐dependent ability to enhance the activity of conditioned medium. We concluded that glutamate can enhance the release and/or activity of CNS derived sprouting factor(s) present in conditioned medium. The general conclusion to be drawn from this study is that the ability of a neurotrophic factor(s) to promote neunte outgrowth can be regulated by a neurotransmitter. This mechanism may be important in the regulation of trophic factors in the adult nervous system.