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Malic enzyme activity in the developing rat brain in relation to thyroid status
Author(s) -
Thakare U. R.,
Shah D. H.,
Vijayan U.
Publication year - 1989
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(89)90070-1
Subject(s) - triiodothyronine , propylthiouracil , malic enzyme , endocrinology , medicine , hormone , offspring , enzyme , thyroid , enzyme assay , developmental profile , biology , pregnancy , biochemistry , genetics , dehydrogenase
Malic enzyme activity in the soluble fraction of neonate brains from mothers fed with propylthiouracil (0.015% w/v) in drinking water from day 12 of the gestation period was significantly lowered ( P < 0.01 ) as compared to the offspring of normal mothers. Supplementation of triiodothyronine to the neonates from experimental mothers restored the malic enzyme activity to normal levels. However, administration of triiodothyronine to adult control rats did not influence malic enzyme activity in the brains of these animals. Our data suggest that during the initial critical period of brain maturation, malic enzyme is under the control of thyroid hormones. The response of malic enzyme towards thyroid hormones is lost once the brain has matured.