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Developmental changes in 5‐hydroxytryptamine immunoreactivity of sympathetic cells
Author(s) -
Soinila Seppo,
Ahonen Marketta,
Lahtinen Tuija,
Häppölä Olli
Publication year - 1989
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(89)90014-2
Subject(s) - adrenal medulla , catecholamine , serotonin , tryptophan hydroxylase , immunohistochemistry , endocrinology , biology , medicine , medulla , chemistry , receptor , serotonergic
5‐Hydroxytryptamine was demonstrated immunohistochemically in developing sympathetic chain ganglia, adrenal medullae and retroperitoneal paraganglionic tissue. Initially, all catecholamine‐synthesizing cells were immunoreactive to 5‐hydroxytryptamine, but during the maturation some sympathetic cell types lose this property. In the ganglia, small intensely fluorescent cells retain their 5‐hydroxytryptamine content throughout maturation. This property is expressed transitionally in some neonatal principal neurons, but can be triggered even in adult neurons, e.g. after loading with l ‐tryptophan. In the adrenal medulla, immunoreactivity to 5‐hydroxytryptamine is carried over to the adrenaline‐synthesizing cells, while in the main retroperitoneal paraganglion it is observed in both adrenaline and noradrenaline cells. These results suggest that initial expression of 5‐hydroxytryptamine immunoreactivity is coupled to the onset of catecholamine synthesis, but is regulated differently in each mature sympathetic organ.