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Stimulation of neurite outgrowth in vitro by a glycero‐ganglioside
Author(s) -
Cannella Michael S.,
Acher Aureliu J.,
Ledeen Robert W.
Publication year - 1988
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(88)90015-9
Subject(s) - ganglioside , sialic acid , stimulation , neurite , in vitro , chemistry , biochemistry , ceramide , diglyceride , lactosylceramide , oligosaccharide , microbiology and biotechnology , glycolipid , biology , neuroscience , fatty acid , apoptosis
A glycerol‐containing analog of ganglioside, with sialic acid attached to a diglyceride‐like structure possessing two ether‐linked alkyl chains, was prepared synthetically and applied exogenously to three culture systems; neuro‐2A neuroblastoma cells, PC12 cells and dorsal root ganglia. This resulted in pronounced stimulation of neunte outgrowth in all three, demonstrating that sialo‐lipids(s) lacking ceramide and possessing sialic acid as the sole carbohydrate are able to promote neuritogenesis in approximately the same manner as naturally occurring gangliosides.