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Rates of protein synthesis in brain and other organs
Author(s) -
Shahbazian F. M.,
Jacobs Myron,
Lajtha Abel
Publication year - 1987
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(87)90046-3
Subject(s) - in vivo , spleen , kidney , protein biosynthesis , medicine , biology , lung , endocrinology , biochemistry , microbiology and biotechnology
We previously found a decrease in protein synthesis in brain during development, which was much greater as measured in brain slices than in brain in vivo . In the present work such changes in brain were compared to those in other organs. With measurement of incorporation of flooding doses of [ 14 C]valine into proteins of organs, the highest synthesis rate in the adult animal in vivo was found in liver (2.2%) followed by kidney (1.8%), spleen (1.6%), lung (1.0%), heart (0.7%), brain (0.6%) and muscle (0.5%). In immature animals the synthesis rate was highest in spleen (2.6%) followed by liver (2.4%), kidney (1.7%), lung (1.6%), brain (1.5%), heart (1.1%), and muscle (0.9%). Protein synthesis in slices from each tissue proceeded at lower rates than in vivo , especially in adults. The tissue affected the most by the preparation of the slices was muscle.