Premium
Current aspects of the development of the blood‐brain barrier
Author(s) -
Joó Ferenc
Publication year - 1987
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(87)90013-x
Subject(s) - blood–brain barrier , brain development , neuroscience , endothelium , biology , central nervous system , endocrinology
Results of earlier studies clearly indicated that, during development, a number of enzymes are sequentially expressed in the brain endothelial cells correlating in time with the maturation of brain tissue. More recent data suggested that differentiation of endothelium in the intraparenchymal cerebral microvessels into one with blood‐brain barrier characteristics seems to be induced by astrocytes at a specific time of embryonic development. Details of the above‐mentioned and other important aspects of the development of the blood‐brain barrier will be discussed in the present mini review.