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Acquisition of acoustic startle shows a dose‐response to serum free T 4
Author(s) -
Schneider Bernard F.,
Golden Wendy L.
Publication year - 1986
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(86)90057-2
Subject(s) - acoustic startle reflex , startle response , moro reflex , reflex , thyroid , hormone , medicine , endocrinology , neuroscience , biology
Methimazole, administered to rats in drinking water (0.1 and 0.05%) from embryonic day 17 to postnatal day 10, caused a dose‐dependent decrease in serum Free T 4 and an accompanying dose‐dependent delay in acquisition of acoustic startle reflex. In conjunction with other studies showing the specific dependence of acoustic startle development on thyroid hormone, this study suggests that the acoustic startle system may be a useful model for determining thyroid hormone requirements for normal neurologic development.