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Multiple forms of aryl acylamidase in regional tissues of developing rat brain
Author(s) -
Hsu Louise L.
Publication year - 1986
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(86)90044-4
Subject(s) - aryl , chemistry , organic chemistry , alkyl
The specific activities of two forms of aryl acylamidase (AAA) were examined in 7 regions of the developing rat brain, plus the remainder of the brain and the whole brain. AAA‐1 activity peaked at 15 days old in all brain regions studied except the whole brain where it peaked at 22 days of age. AAA‐2 activity peaked between 15 and 29 days old in most brain regions studied except corpus striatum and hippocampus where the AAA‐2 activity peaked before 15 days old. In all areas and at all time periods, with the exception of CS after 15 days of age, AAA‐2 activity was much higher than that of AAA‐1. The developmental pattern of AAA‐1 is generally the same in the different brain regions while that of AAA‐2 shows more regional specificity. These results indicate that neither AAA‐1 nor AAA‐2 may be associated with amine N‐acetyltransferase in the brain which has an entirely different developmental pattern.