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Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats
Author(s) -
Ohkura Takeyoshi,
Lee J. W.,
Hagino N.
Publication year - 1986
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(86)90037-7
Subject(s) - dopamine , norepinephrine , endocrinology , medicine , neuroscience , psychology
Hypothalamic dopamine (DA) and norepinephrine (NE) concentrations were studied in the neonatal rats after acute (postnatal day 4) or chronic (postnatal days 1–10) DA injections (0.5 mg in 5% dextrose in 0.45% saline). Acute injection of DA twice on postnatal day 4 resulted in an increase of hypothalamic DA and NE concentrations 16 hr later. Chronic treatment with the DA (twice in a day) for 10 days resulted in a reduction of NE concentration in the hypothalamus. The results of these studies suggest that the amount and duration of exposure to exogenous DA during postnatal development may result in divergent effects on hypothalamic catecholamine concentration.