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A morphometric study of mouse trigeminal roots after unilateral destruction of vibrissae follicles at birth
Author(s) -
Savy C.,
Margules S.,
Solari A.,
Wehrle R.,
Verley R.,
FarkasBargeton E.
Publication year - 1986
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(86)90010-9
Subject(s) - axon , anatomy , sprouting , sensory system , trigeminal nerve , myelin , myelin sheath , biology , atrophy , neuroscience , central nervous system , botany , genetics
Trigeminal sensory roots were studied in neonatal mice. On the deafferented side, the surface area of the cross‐section through the sensory root is diminished by 31% and the number of myelinated fibers is reduced by 21%. but the proportion between myelinated and unmyelinated fibers remains unchanged. The distribution of axonal diameters, analysed in 7 dorso‐ventral scanning bands through the sensory roots, indicates a loss or eventually an atrophy of large myelinated axons in the medial two thirds of the sensory root. In both control and deafferented sides the diameter of the myelinated fiber (outside the myelin sheath) is proportional to the axon diameter (inside the myelin sheath). Our results confirm the loss of most of the neurons innervating vihrissae and the lack of regeneration or sprouting in the deafferented root in the newborn mouse.