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Sex and estrous cycle differences in GABA and glutamate concentrations in discrete brain regions of the adult rat
Author(s) -
Frankfurt H.,
Fuchs E.,
Wuttke W.
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90250-3
Subject(s) - german , primate , center (category theory) , estrous cycle , neuroscience , biology , philosophy , endocrinology , chemistry , linguistics , crystallography
Gabaculine, a specific inhibitor of Gaba-transaminase, has been used( lOOmg/kg ) to determine GABA turnover rates (Bernasconi et al . , J. Neurochem., 1982, 38, 57-66) in 15 brain areas of 3 inbred strains of 21 day or 3 month old mice (DBAT~J-C57/B16JSwiss Rbl). At the age of 3 months the brain areas can be grouped according to turnover rates in 2 classes, high (HTR) or low (LTR), regardless of GABA levels. In the HTR areas (septum, frontal cortex, hippocampus, amygdala, hypothalamus, olfactory bulb) turnover rates are correlated with the GABA levels (P <.01), the regression coefficient being not significantly different (.011) for the 3 strains. In the LTR areas (pons, cerebellum, substantia nigra, anterior and posterior colliculus, raphe, striatum, olfactory tubercle, thalamus) turnover rates are not correlated with the GABA levels. At the age of 21 days the brain areas can be grouped in only 1 class (HTR). Turnover rates and GABA levels are correlated (P <.01) only in the DBA/2J and C57/B16 strains, the regression coefficient" being not significantly different (.021).