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Studies on serotonergic and catecholaminergic systems in mice after prenatal exposure to phenobarbital
Author(s) -
Yanai Joseph,
Sze Paul Y.,
Melamed Eldad
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90243-6
Subject(s) - hebrew , philosophy , dept , medicine , classics , psychology , history , immunology
Neonatal t hy ro id dysfunct ion can a f f ec t the b inding process of several neurotransmit ters and other l igands. Receptor a l t e ra t i ons may resu l t from mu l t i p l e inf luences of the procedure used to provoke dysthyroidism. Th is is p a r t i c u l a r l y t rue in c h e m i c ~ l l y i n d u c e d h y p o t h y r o i d i s m , when a severe impairment of brain development may be partially masked From mem brahe effects of the antithyroid dr~Jg used. For example, methimazole (MMl)-provoked hypothyroidism increElsed the number of brain 5-HT rece£ tots, and decreased the density of cortical imipramine (IMI) receptors. However, incubation of brain membranes with MMI, propylthiouracyl and additional sulfhydryl reagents decr,~ased the number of 5-HT I, and increa sod the number of IMI binding sites, thus an effect opposite to that of in vivo administration of MMI. The .-SH content was similar in euthyroid and hypothyroid membranes, thus sugt~esting tha t retarded synaptogenesis, and not -SH perturbances in hypothyr'oidism, was a major cause For a l te ra t i o n s in IMI b i n d i n g .