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Transient expression of tyrosine‐hydroxylase (TH) in amacrine cells of the developing rat retina
Author(s) -
Jeanine NguyenLegros,
Claudine VersauxBotteri,
Annette Vigny,
Nadine Raoux
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90240-0
Subject(s) - citation , tyrosine hydroxylase , transient (computer programming) , retina , computer science , library science , neuroscience , biology , dopamine , programming language
Hypothalamic neuropeptides are involved in central neural functions besides p i tu i ta ry or other endocrine glands regulat ion. Since MIF and TRH can exert a profound interferen ce on DOPA and 5-HT systems, and these hypothalamic neuropeptides are present ear ly in brain development, i t is of in terest to invest igate the ef fects induced by these substances on brain funct ion growth of small mammals. In the present study animals were tested da i l y with a battery of ref lexes from the f i r s t to the 21st day of l i f e . l ng~ups of animals at 12,16 and 19 days of age a computerized electroencephalographic (EEG) an~ ysis was performed to examine the evolut ion of power spectra with pa r t i cu la r referenceto the re la t ionsh ip between the theta range power of EEG and motor a c t i v i t y in these ages. At 30 days of age, groups of animals underwent a set of behavioural t r i a l s , test ing spontaneus motor a c t i v i t y , condi t ioning and learning. Prel iminary resu l ts showed that chron ica l l y administered hypothalamic factors can induce, even at low dosages, profound a l te ra t ions on the dynamic re lat ionships between the behaviour and EEg of animals. These e f fec ts , which cannot be evident iated in acutely treated animals, may cont r i bu te to better e luc idat ion of the inf luence exerted by hypothalamic hormones on the evolut ion of brain neuromodulators and the i r inf luence in animal behaviour.