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Age‐related changes in acetylcholine receptor degradation rate
Author(s) -
Amedeo M.R.,
Robecchi M. G. Giacobini,
Filogamo G.
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90223-0
Subject(s) - citation , computer science , library science
Systemic pilocarpine {PILO] induces epileptiform activity with limbic motor seizures and widespread brain damage of adult rats {Turskl et a l . , 1983). Behavloral and EEG changes induced by PILO 100-400 mg/Kg in developing rats are reported. Hyperactivity, tremors and clonCo movements of head and limbs were observed during the 1st. 2-weeks of life, shortly after PILO Injectlon. Sporadlcally, mastlcatery movements and crying were also noted. These manifestations lasted up to 3 h. No animal death occured with all used doses of PILO. It was observed during the 3rd. week of life, and in addition to the motor signs, wet dog shakes and llmblc seizures which became frequent culminating in a status epilepticus with death of some rats. The EEG changes included spikes or polispikes Cn the hlppocampus and cortex during the 1st. week of life, and pr±mary hippocampal discharges with posterior involvement of the cortex from the 2nd. week of life on to adult life. Typical adult electrographlc status epileptlcus was seen after the 14th. day of llfe. Progressive sensitivity increase to PILO of neonatal rats may be related to the immaturity of muscarinic cholinergic receptors. Developmental s~:udies have demonstrated that eholinergic hlppocampal system appears around post-natal day 4 and seems te be completed by the 3rd. week of iife, thus supporting our results.