Premium
Hypoxia induced changes in the developing hippocampus
Author(s) -
Pokorný J.,
Trojan S.
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90128-5
Subject(s) - trojan , citation , hypoxia (environmental) , computer science , information retrieval , library science , psychology , computer security , chemistry , organic chemistry , oxygen
Laurence D. Fa, Michael Karpa & Jan E. Storm Johns Hopkins University, Baltimore. MD 21205 USA We are assessing the effects of mild prenatal carbon monoxide exposure as a model of maternal cigarette smoking and to address issues of sensitivity of the developing brain to chronic mild hypoxia and mechanisms by which hypoxia disrupts neuronal developanent. Pregnant rats were chronically exposed to carbon monoxide levels producing carboxyhemoglobin values ranging from 9-24%. Following characterization of postnatal growth patterns, offspring were sacrificed at weekly intervals between 14 and 35 days of age for determination of neostriatal neurochemical development; neuroanatomical and clinical data have demonstrated that acute carbon monoxide intoxication disrupts this structure. The normal developmental pattern of dopamine content did not differ between groups at any age tested. However, significant elevation of DOPAC levels were noted in 14 day old pups suggesting alterations in rate of dopamine metabolism. No change in HVA levels were observed. Hesponsivity of dopamine neurons in carbon monoxide treated subjects to haloperidol will be presented. Selected Communications