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The in vitro neoplastic transformation of glial cell subpopulations
Author(s) -
Vellis Jean,
Bressler Joseph P.,
Luner Stephen J.
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90117-0
Subject(s) - library science , citation , glioblastoma , medicine , gerontology , cancer research , computer science
In the experimental induction of cerebral tumors, the transplacental ENU model produced a great deal of information. Already classified the mechanisms of DNA damage and repair: two problems remain still open: the sequential phenotypic alterations in the target cells and the relationship between tumorigenesis and cytogenesis. The histochemical and biochemical study of GAGS in the brain and in the tumors at different developmental stages as well as the application of immunohistochemical techniques, such as that for GFAP, gave useful information about cell differentiatLon and tumor progression. GAGS do not accumulate before the appearance of the early neoplastic proliferations and seem to partially correlate with the normal nervous tissue trapped in the tumors. GFAP demonstrate that many reactive astrocytes occur in the early neoplastic proliferations.