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Functional and structural properties of cell adhesion molecules
Author(s) -
Schachner M.,
Faissner A.,
Kruse J.,
Wernecke H.,
Mailhammer R.,
Goridis C.
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90092-9
Subject(s) - library science , computer science
Cell surface antigen Ll recognized by monoclonal antibodies is involved in Ca++-independent adhesion among neural cells and in migration of granule cells in the early postnatal cerebellar cortex. It is structurally and functionally distinct from the N-CAM related group of antigens and is co-expressed with N-CAM on post-, but not premitotic neurons. The two adhesion molecules act in synergism and mediate adhesion between different cell types. Structural similarities between these molecules are recognized by several antibodies designated L2. These antibodies react additionally with other glycoproteins which may be implicated in cell adhesion.