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Distribution of pipecolic acid and proline in the developing rat brain and peripheral organs
Author(s) -
Nishio Hiroaki,
Yamada Yutaka,
Giacobini Ezio,
Segawa Tomio
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90072-3
Subject(s) - pipecolic acid , proline , medicine , endocrinology , amino acid , biology , period (music) , kidney , chemistry , biochemistry , physics , acoustics
The regional distribution of pipecolic acid and proline was studied in the adult and newborn rat brain. The brain concentration of pipecolic acid in the 1 and 3‐day‐old rat was 6–10 times higher than in the adult. The brain concentration of proline was found to be about 3 times higher in the brain of a newborn rat than in the adult, then it gradually decreased during the period of lactation. In plasma as well as in peripheral tissues, such as heart, kidney and liver, the highest concentration of pipecolic acid was observed at 1 day and in the adult. Secretion of pipecolic acid into the urine was highest at early stages of development. In the gastrointestinal tract, pipecolic acid was found to be most abundant in the adult, whereas low levels were found during the period of lactation. The developmental and regional changes in concentration of proline were quite different from those of pipecolic acid. Our results suggest that the contribution of dietary pipecolic acid in building up levels of pipecolic acid in rat brain is small.