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The microtubular apparatus of cerebellar purkinje cell dendrites during postnatal development of the rat: The density and cold‐stability of microtubules increase with age and are sensitive to thyroid hormone deficiency
Author(s) -
Faivre C.,
Legrand Ch.,
Rabié A.
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90045-0
Subject(s) - microtubule , purkinje cell , ultrastructure , biology , thyroid , medicine , endocrinology , chemistry , microbiology and biotechnology , cerebellum , anatomy
A quantitative ultrastructural study of microtubules in Purkinje cell dendrites of normal and hypothyroid developing rats was performed after fixation either at room or at low temperature (4°C). In normal animals, the density of microtubules and their fold‐stability increased with age, more especially during the period of intense dendritic growth. Thyroid deficiency delayed the appearance of microtubules and still more the acquisition of their fold‐stability. These effects might explain the defects in Purkinje cell dendritic growth and branching observed in hypothyroid animals.