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The phagocytes of neonate rat primary mixed glial cultures
Author(s) -
DuBois J.H.,
HammondTooke G.D.,
Cuzner M.L.
Publication year - 1985
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(85)90042-5
Subject(s) - opsonin , central nervous system , antigen , microbiology and biotechnology , biology , neuroscience , immunology , receptor , microglia , primary culture , phagocytosis , cell culture , inflammation , biochemistry , genetics
The phagocytes present in mechanically dissociated neonate rat cerebral hemispheres have been cultured and characterized both qualitatively and quantitatively. They comprise about 10% of the starting cell suspension and persist but do not proliferate in culture. They do not possess neuronal or neuroglial antigens but do express the leukocyte common antigen and readily ingest both latex beads and opsonized erythrocytes. the latter by an Fc receptor‐mediated process. Evidence is presented that these cells are a bona fida component of the neonate central nervous system.