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Behavioral effects of phosphatidylserine after perinatal administration in rats
Author(s) -
Drago F.,
Continella G.,
Alloro M.C.,
Presti L. Lo,
Scapagnini U.
Publication year - 1984
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(84)90071-6
Subject(s) - offspring , phosphatidylserine , gestation , pregnancy , medicine , endocrinology , physiology , phospholipid , biology , biochemistry , genetics , membrane
Behavioral effects of the acidic phospholipid phosphatidylserine (PS) were studied in rats after perinatal (prenatal or neonatal) administration. PS was administered to pregnant rats from day 5 of pregnancy. PS liposomes were also injected i.p. to offspring from postnatal days 1–5. PS‐treated rats showed a more precocious onset of neonatal behaviors, and a significant improvement in acquiring avoidance responses when tested at 60 days of age. Behavioral effects of PS may be related to a possible influence on dendritic arborization during perinatal period.