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Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity
Author(s) -
Yanai Joseph,
Fishman Rachelle H.B.
Publication year - 1984
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(84)90060-1
Subject(s) - barbiturate , pentobarbital , dopamine , haloperidol , dopamine receptor , receptor , endocrinology , medicine , dopamine receptor d1 , neuroscience , dopamine receptor d2 , chemistry , biology , pharmacology
Adult rats whose dopamine receptor number was reduced via prenatal haloperidol exposure were less resistant than controls to pentobarbital narcosis. This altered resistance was functional (CNS) and not metabolic, as shown by pentobarbital brain levels. These results are consistent with our previous experiments, indicating that changes in the number of dopamine receptors may underlie relative susceptibility to barbiturates.