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Monosialoganglioside internal ester stimulates the dopaminergic reinnervation of the striatum after unilateral hemitransection in rat
Author(s) -
Aldinio Caterina,
Valenti Giacomina,
Savoini Gian Enrico,
Kirschner Guenter,
Agnati Luigi F.,
Toffano Gino
Publication year - 1984
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(84)90021-2
Subject(s) - reinnervation , striatum , tyrosine hydroxylase , dopaminergic , chemistry , medicine , tyrosine , dopamine , endocrinology , neuroscience , biochemistry , biology
The effects of the administration of GM 1 monosialoganglioside internal ester, AGF 2 , on the dopaminergic reinnervation of the striatum in rats with unilateral hemitransection has been studied. AGF 2 increases the apparent V max and the density of tyrosine‐hydroxylase‐positive nerve terminals in the striatum of the lesioned side, without modification of the tyrosine‐hydroxylase activity in the unlesioned side. AGF 2 , at lower doses, is more active than its parent natural molecule GM 1 . AGF 2 has a larger half‐life and a higher distribution volume than GM 1 , and undergoes a slow hydrolysis in the serum releasing the original natural compound GM 1 . Mannitol and dexamethazone, often used to prevent swelling of the brain after injury, or isoaxonine, proposed to stimulate neurite growth are unable to reproduce the effects of AGF 2 on the recovery of striatal tyrosine‐hydroxylase activity after hemitransection. The data are compatible with the view that AGF 2 , through its conversion into GM 1 , facilitates the collateral sprouting of the nigro‐striatal dopaminergic neurons.