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Developmental manipulations of dopamine receptors modulate sensitivity to barbiturate
Author(s) -
Yanai J.,
Fishman R.H.B.
Publication year - 1983
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(83)90376-3
Subject(s) - hebrew , psychology , presentation (obstetrics) , medical school , humanities , medicine , classics , philosophy , history , medical education , surgery
Developmental Manipulations of Dopamine Receptors Modulate Sensitivity to Barbiturate Yanai, J. and Fishman, R.~.B. The Hebrew University-Hadassah Medical School, Department of Anatomy & Embryology, 91010 Jerusalem, Israel. In our previous experiments, when post-synaptic dopamine (DA) receptors of adult mice were made supersensitive, they possessed a lesser CNS sensitivity to ethanol and barbiturate. A reciprocal and complementary experiment was conducted. Pregnant sabra rats received twice daily S.C. injection of 2 mg/kg halperidol (H) on gestation days 14 to 18, in order to induce DA receptors subsensitivity in the treated offspring. Control and H offspring were tested at adulthood for pentobarbital, (PenB; 40mg/kg) induced sleep time. H females and males slept 43% and 81% longer than their controls, respectively (p