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Structural and functional studies on neural cell surface glycoproteins
Author(s) -
Goridis C.,
Hirn M.,
Liabeuf A.,
Rougon G.,
Sadoul R.
Publication year - 1983
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(83)90301-5
Subject(s) - humanities , chemistry , philosophy
Ceil sur face g lycopro te ins present in the deve lop in Z mouse nervous system have beetl ident i f ied by monoc lona l ant ibodies. Two of them, named BSP-2 and NSP-4, exLst ~n mu] t ip le molecu lar forms wh ich are se lect ive ly expressed in d i f ferent nervous t issues and dur in Z development . Evidence wi l l be presented ind icat in Z that these d i f ferent forms are created by d i f ferent g lyeosy la t ion pa t te rns of common po lypept ide backbones. A third surface g lycoprote in , o r ig ina l l y named BSP-3, has now been ident i f ied as the i:i-subunit of the Na+, K+-dependent ATPase. BSP-2 seems to be identical wi th the neura] ceil adhes ion molecu le N-CAM. Studies us in Z pur i f ied BSP-2 reconst i tu ted into lipid vesic les show that the d i f fe rences in its carbohydra te s t ructure have profound inf luences on the b ind ing proper t ies of the molecule. ] 'he resul ts wi l l he d iscussed ~n re lat ion to the in v i t ro and in vivo ]ocat isa t ion of the ZSP-2 and BSP-3 ant izens.