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Studies of accelerated development and aging in human neuroblastoma cells: A model for Alzheimer's disease
Author(s) -
Sternberg H.,
Timiras P.S.
Publication year - 1983
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(83)90282-4
Subject(s) - citation , gerontology , library science , neuroscience , cognitive science , medicine , psychology , computer science
This presentation will review approaches aimed at two disorders--Huntington's Disease (H.D.), in which there is substantial degeneration of the caudate/putamen/globus pallidus, leading to observable pathological and neuorchemical changes; and tardive dyskinesia, in which side effects of neuroleptic drugs are presumed to be operating within the striatum, but no pathological correlates have been described, and the neurochemical changes tend to be complex and somewhat variable. In order to investigate the cellular effects of neuroleptics on the striatum, primary monolayer cultures of the rat striatum were treated with low concentrations of trif luoperazine. Treated cells appeared morphological ly identical to controls, but showed significant reductions in synthesis of acetylcholine and~r'-aminobutyric acid, part icularly the former. For H.D., strategies of searching for intrinsic neuronal differences, trophic and glial effects, and the use of animal cultures to screen human extracts will be discussed, including the feasibil i ty of the various types of studies. Supported by the Hereditary Disease Foundation and NIH grant # NS 17633-02.