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Opiate receptors during early embryogenesis
Author(s) -
Vernadakis A.,
Gibson D.A.,
Sakellaridis N.
Publication year - 1983
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(83)90272-1
Subject(s) - medicine , opiate , library science , classics , history , receptor , computer science
In primary astroglia-rich cell cultures derived from newborn mouse or rat brain the hormones regulating the intracellular concentration of cyclic AMP can be divided in two classes, those that elevate and those that inhibit this elevation. Among these hormones are peptides such as secretin, adrenocorticotropin, melanotropins, parathyrin, calcitonin (stimulating) and somatostatin (inhibitory). The maximal response to parathyrin increases with time in culture. The implications of these findings for peptide hormone action in brain, for glial cell function, heterogeneity and development will be discussed.