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Monoamine neurotransmitters in the early chick embryo: localization, synthesis and analysis of transmitter‐concentrating mechanisms
Author(s) -
Wallace J.A.
Publication year - 1983
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(83)90267-8
Subject(s) - monoamine neurotransmitter , citation , library science , neuroscience , computer science , psychology , biology , genetics , serotonin , receptor
Lauder, J.M., Dept. of Anatomy, Univ. of N.C., Sch. ol Medicine, ChaT)e[ Hill, N.C. 27514, USA In a previous study (Lauder and Krebs ]978) we found changes in the time of neuronal genesis in the brains of offspring from mothers treated with the serotonin (5-HT) synthesis inhibitor, p-ch]orophenylalanine (pCPA). These effects occurred only in brain regions which receive a serotonergie innervation in the adult hr,]in. [11 ~ subsequent study, (Lauder et al., 1981), we demonstrated that maternal pCPA treatment seve~ly inhibits 5-HT synthesis (tryptophan hydroxylase activity) in the embryonic rat brain. Recently, (Lauder et al., 1982) we correlated the neurogenic eflects of pCPA with patterns oF developing 5-HT axons innervating the embryonic rat brain, using anti-5-HT immunocytocbemistry. These comparisons have demonstrated that only in regions where 5-HT axons arrive during initial phases of neuronal differentiation can pCPA cause delayed or prolonged neuronal genesis. Moreover, our latest studies indicate that this same treatment has the ability to decrease ]eve]s of 5-HT in the whole embryonic ])rain (ttPLC aoa]vsis) as well as in individual 5-I{l neurons, ("en-bloc" ]mmunotitration method). Taken together, these resu]ts suggest that 5-11"I coutain(d in developing axons of raphe neurons may exert epigenetie influences on the dif~er(mtiation oi their target cel]s durin Z "critical periods" for neuronal genesis in the embryonic rat brain.