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Nutrient and metabolic requirements of the developing central nervous system
Author(s) -
Organizer Edmond J.
Publication year - 1983
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(83)90223-x
Subject(s) - citation , library science , gerontology , computer science , neuroscience , psychology , medicine
The metabolic capacity of the developing central nervous system for the major functions of energy production and lipogenesis is to be presented from several perspectives. Emphasis is to be placed on the development and regulation of enzymes which are critical to energy metabolism and to the biosynthesis of lipids, particularly of cholesterol. Complementary to the discussions of enzymic capacities which reflect metabolic potential will be presentations dealing with studies which identify the fuels of cerebral energy metabolism and the substrates which serve as significant carbon sources for lipogenesis during active myelination. Model systems which permit the study of metabolic capacity in a discrete way, and lead to the understanding of central nervous system function in terms of the metabolic specialization of specific cell populations., the metabolic function and capacity of discrete brain regions and the compartmentation of metabolic processes at the subcellular level will all be highlighted in delineating nutrient requirements for the course of development.