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Serotonin as a stimulator of hippocampal cell differentiation in tissue culture
Author(s) -
Gromova H. A.,
Chubakov A. R.,
Chumasov E. I.,
Konovalov H. V.
Publication year - 1983
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(83)90015-1
Subject(s) - hippocampal formation , synaptogenesis , neuropil , neuroscience , biology , tissue culture , serotonin , electrophysiology , bursting , axon , microbiology and biotechnology , central nervous system , in vitro , receptor , genetics
The effects of serotonin (5‐HT) on morphofunctional development of hippocampal cultures derived from newborn rats were studied. It was established that systematic addition of 5‐HT to nutrient medium during cultivation stimulates neuropil development, axon myelination and synaptogenesis. Electrophysiological studies of hippocampal cells in 5‐HT treated cultures showed earlier exhibition of spontaneous activity and an increased number of spontaneously firing neurons and prevalence of periodic (bursting) type of discharges. These results indicate that 5‐HT stimulates the differentiation of hippocampal cells in tissue culture.