Premium
L5: A carbohydrate epitope involved in neural development
Author(s) -
Streit Andrea,
Stern Claudio D
Publication year - 1995
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/0248-4900(96)81319-0
Subject(s) - biology , epitope , gastrulation , neural development , central nervous system , neuroscience , microbiology and biotechnology , neural plate , neural tube , immunology , biochemistry , embryogenesis , embryo , antibody , gene
Summry— The L5 carbohydrate epitope is developmentally regulated in the vertebrate nervous system, both at very early stages (neural induction) and during postnatal development. Here, we review the evidence indicating that, during gastrulation, L5 may be a marker for cells competent to respond to neural inducing signals emanating from Hensen's node (the ‘organizer’) and that it may itself be involved in the response to neural induction. In postnatal cerebellar development, when L5 is found on astrocytes, it participates in the outgrowth of astrocytic processes on extracellular matrix components. Finally, we indicate the structural relatedness of the L5 carbohydrate and Le x , CD15 and SSEA‐1.