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Adriamycin resistance is characterized by ultrastructural changes in human leukaemic K562 cells in vitro
Author(s) -
Bobichon He´le´ne,
Okiemi MarieGenevieve,
Broglio Christine,
Ploton Dominique,
Dufer Jean
Publication year - 1992
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/0248-4900(92)90040-8
Subject(s) - ultrastructure , nucleolus , k562 cells , biology , in vitro , cell culture , chromatin , microbiology and biotechnology , cell , nucleus , anatomy , dna , biochemistry , genetics
Summary— Ultrastructural changes associated with adriamycin (ADM) resistance have been investigated in the human K562 leukaemic cell line: sensitive K562 cells, a resistant subline cultured in the continuous presence of ADM and resistant cells without ADM Transmission electron microscopy (TEM) study revealed that K562‐resistant cells displayed ultrastructural modifications of the cell surface, chromatin and nucleolus conformation. Alterations were not directly related to the presence of adriamycin as deprivated cells exhibited modificated characters through a slow progressive recovery phenomenon.