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Intracellular boron localization and uptake in cell cultures using imaging secondary ion mass spectrometry (ion microscopy) for neutron capture therapy for cancer
Author(s) -
Bennett Brian D.,
Zha Xiaohui,
Gay Isabelle,
Morrison George H.
Publication year - 1992
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/0248-4900(92)90015-s
Subject(s) - boron , intracellular , neutron capture , microscopy , mass spectrometry , biology , cell , subcellular localization , secondary ion mass spectrometry , biophysics , ion , radiochemistry , microbiology and biotechnology , biochemistry , chemistry , chromatography , pathology , cytoplasm , medicine , organic chemistry
Summary— Quantitative ion microscopy of freeze‐fractured, freeze‐dried cultured cells is a technique for single cell and subcellular elemental analysis [1–3]. This review describes the technique and its usefulness in determining the uptake and subcellular distribution of the boron from boron neutron capture therapy drugs.