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Cellular and subcellular localization of annexin IV in rabbit intestinal epithelium, pancreas and liver
Author(s) -
Massey Dominique,
Traverso Valérie,
Rigal Alain,
Maroux Suzanne
Publication year - 1991
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/0248-4900(91)90097-7
Subject(s) - biology , pancreas , immunofluorescence , annexin , annexin a1 , cytoplasm , epithelium , annexin a2 , monoclonal antibody , microbiology and biotechnology , pathology , antibody , endocrinology , immunology , flow cytometry , medicine , genetics
Summry— The results of immunoblot analysis performed with a specific monoclonal antibody showed that the intestinal mucosa, pancreas and liver are privileged tissues for the expression of annexin IV. Immunofluorescence labelling of thin frozen sections of these tissues showed a strong concentration of annexin IV along the basolateral domain of the plasma membrane of intestinal absorbing cells, hepatocytes and pancreatic acinar cells, whereas in intestinal mucous secreting cells and centro acinar pancreatic cells, annexin IV was found to be present throughout the cytoplasm.