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Sodium butyrate inhibits c‐ myc and stimulates c‐ fos expression in all the steps of the cell‐cycle in hepatoma tissue cultured cells
Author(s) -
Tichonicky Lydie,
Kruh Jacques,
Defer Nicole
Publication year - 1990
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/0248-4900(90)90329-2
Subject(s) - sodium butyrate , cycloheximide , butyrate , biology , messenger rna , c fos , cell cycle , microbiology and biotechnology , cell , cell culture , sodium , gene expression , biochemistry , protein biosynthesis , gene , chemistry , genetics , fermentation , organic chemistry
Summary— Soduim butyrate decreases the c‐ myc mRNA and increases the c‐ fos transcript level in HTC cells. This effect is independent of the cell‐cycle phase. Actinomycin D suppresses the effect on c‐ fos . Cycloheximide increases both mRNA levels. Sodium butyrate suppresses the effect on c‐ myc and potentializes the effect on c‐ fos mRNAs. This suggests that sodium butyrate acts at the transcriptional level and that its effect does not result from the arrest of the cells at the G1 phase.