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EXPRESSION OF THE c‐fos PROTO‐ONCOGENE IN BONE, CARTILAGE AND TOOTH FORMING TISSUES DURING MOUSE DEVELOPMENT
Author(s) -
CAUBET JeanFrançois,
BERNAUDIN JeanFrançois
Publication year - 1988
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/0248-4900(88)90100-1
Subject(s) - biology , cartilage , oncogene , microbiology and biotechnology , expression (computer science) , anatomy , genetics , gene , cell cycle , computer science , programming language
Summry— The c‐fos proto‐oncogene is the cellular homologue of v‐fos identified as the bone transforming gene of the FBJ and the FBR murine osteosarcoma viruses. We show here, using a sensitive in situ hybridization method, that the c‐fos proto‐oncogene is expressed in the cartilage, bone and tooth forming tissues during mouse development. This result suggests that the tumors observed after infection by the FBJ viral complex and c‐fos overexpression in transgenic mice occur in those tissues in which c‐fos is expressed during development.