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Interaction of biological membranes with the cytoskeletal framework of living cells
Author(s) -
MANGEAT PaulHenri
Publication year - 1988
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/0248-4900(88)90001-9
Subject(s) - biology , spectrin , microbiology and biotechnology , membrane , cell cortex , ankyrin , cytoskeleton , actin , membrane protein , cytoplasm , peripheral membrane protein , integral membrane protein , function (biology) , cell , cell polarity , cell membrane , biochemistry , gene
The review is focused on the molecular structure and function of the proteins composing the actin‐based cytokeletal cortex, located at the cytoplasmic face of plasma membranes of eucaryotic cells, which stabilizes integral membrane proteins in separate domains of cell membranes. It includes a survey of the molecular properties of teh proteins of the erythrocyte membrane skeleton such as spectrin, ankyrin, protein 4.1, and adducin. The properties of the immunological counterparts of erythroid cortical proteins found in nonerythroid tissues and cells are compared. The structural organization and function of the newly discovered class of calcium‐binding proteins, nonerythroid peripheral membrane proteins, calpactins, are also described. Finally, the discussion of some experimental models illustrates that the membrane skeleton of living cells is actively involved in a wide variety of essential biological functions ranging from differentiation, to maintenance of cell polarity and cell shape, and regulation of exocytotic processes.