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Sebaceous carcinoma of the vulva: a case report and review of the literature
Author(s) -
Rama P Namuduri,
Mihir Gudi,
Soo Kim Lim Tan
Publication year - 1996
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(96)81557-8
Subject(s) - medicine , vulva , citation , library science , dermatology , computer science
gdactosemia gene (mothers of galactosemic children) experience impaired fecundity and earlier age at natural menopause. Design. Retrospective cohort study comparing experiences of mothers of galactosemic children with mothers of children with phenylketomuia (PKU). Data collection consisted of a structured telephone interview with sections on menstrual, reproductive and medical histories. Participants. One hundred three galactosemia carriers and 116 PKU carriers (mean age. 35.0 and 38.4 years, respectively), recruited from 38 metabolic disease clinics throughout the United States. Main outcome measures. Time-to-pregnancy (a measure of fecundity), menstrual cycle patterns and natural menopause. Results. No differWCC was seen between carriers of the galactosemia and the PKU gene in history of r 12 months of unprotected intercourse without a pregnancy, physician-diagnosed infertility or amenorrhea lasting 26 weeks. The fecundity ratio, adjusting for age. and smoking before most recent pregnancy, was I. 17 (95% C.I. 0.85-1.61). By age 45. 1 I% of gahrctosemia carriers who had not had a hysterectomy reported a natural menopause compared with 4% of PKU carriers (risk difference 7.2%, 95% C.I. -12.7% to 27.1%). Conclusion. Fecundity and other measures of fertility did not differ between mothers of gaiactoscmic children and mothers of children with PKU. Suggestions of an earlier age at natural menopause can not be addressed definitively in this cohort because of the small number of participants who were currently age 45 years or older but may warrant additional assessment as the cohort ages.