Premium
Long‐acting triptorelin for the treatment of endometriosis
Author(s) -
Choktanasiri W.,
Boonkasemsanti W.,
Sittisomwong T.,
Kunathikom S.,
Suksompong S.,
Udomsubpayakul U.,
Rojanasakul A.
Publication year - 1996
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(96)02698-7
Subject(s) - triptorelin , medicine , endometriosis , adverse effect , goserelin , menstruation , luteinizing hormone , bone mineral , urology , gynecology , hormone , gonadotropin releasing hormone , osteoporosis , cancer , breast cancer
Objective: To evaluate the efficacy and adverse effects of monthly triptorelin injection for the treatment of endometriosis. Methods: A multicenter clinical trial including 45 women with endometriosis, treated with triptorelin 3.75 mg i.m. every 4 weeks in six consecutive doses. The main outcome measures were symptom relief, reduction according to revised American Fertility Society (rAFS) scores, reduction in size of ovarian endometrioma, effects on hormone and lipid profiles, changes in bone mineral density (BMD), adverse effects, and return of menstruation. Data were analyzed using repeated measures analysis of variance and paired t‐tests. Results: Pain‐related symptoms decreased in all cases after 8 weeks of treatment. Laparoscopic assessment revealed a reduction in rAFS scores in 21 out of 25 cases (mean pretreatment scores 43.44 ± 5.75 vs. post‐treatment scores 22.30 ± 3.40, P < 0.001). The size of ovarian endometrioma decreased in eight of nine women but none disappeared. Serum luteinizing hormone, follicle‐stimulating hormone and estradiol levels were effectively suppressed during treatment. A slight increase in cholesterol and triglyceride levels was observed but all values were within normal limits. After 24 weeks of treatment there was a slight decrease in BMD of total body, lumbar vertebrae and femoral neck but not radius. The main adverse effects included hot flushes, night sweating, vaginal dryness, headache, dizziness and nausea. Menstruation returned 83.76 ± 2.91 days after the last injection of triptorelin. Conclusion: Long‐acting triptorelin is efficacious in the treatment of endometriosis and has tolerable side effects.