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Plasma glucose and pre‐eclampsia
Author(s) -
Khan K.S.,
Daya S.
Publication year - 1996
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(95)02634-7
Subject(s) - eclampsia , confidence interval , medicine , odds ratio , plasma glucose , logistic regression , diabetes mellitus , obstetrics , pregnancy , endocrinology , biology , genetics
Objective: To determine whether there is a relationship between plasma glucose level in a glucose screening test and the occurrence of pre‐eclampsia in non‐diabetic pregnant women. Methods: All pregnant non‐diabetic women attending the antenatal clinic at the Aga Khan University Medical Center were screened with a 75 g — 2 h glucose challenge test (GCT). From 1988–1990, a data base of 1316 cases was compiled for use in this study. Of these, 67 had to be excluded because of one or more abnormal levels in the 75 g — 3 h oral glucose tolerance test (GTT) that required treatment to maintain euglycemia. Among the remaining patients (n = 1249) who had no evidence of glucose intolerance and were included in the analysis, there were 42 cases of pre‐eclampsia. The association between pre‐eclampsia and plasma glucose level in the GCT was evaluated using logistic regression analysis that adjusted for effects of age and gravidity. Results: The odds of having pre‐eclampsia were increased by 20% (95% confidence interval 0%–44%) per mmol/1 rise in plasma glucose level in the GCT. The same statistic for age was 9% (95% confidence interval 2%–17%), and for primigravidity it was 210% (95% confidence interval 55%–517%). There was no significant interaction between these variables. Conclusions: Minor degrees of glucose intolerance, age and primigravidity are associated with a higher occurrence of pre‐eclampsia in non‐diabetic pregnant women.