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Effect of postmenopausal estrogen replacement therapy on lipoproteins
Author(s) -
Omu A.E.,
AlQattan N.
Publication year - 1996
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(95)02578-2
Subject(s) - medicine , estrogen , progestin , menopause , lipoprotein , endocrinology , hormone replacement therapy (female to male) , lipoprotein(a) , body mass index , norgestrel , cholesterol , hormone therapy , physiology , population , breast cancer , family planning , testosterone (patch) , cancer , environmental health , research methodology
Objectives: To investigate the association between menopause and lipoproteins and the effect of hormone replacement therapy (HRT). Methods: Total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were estimated in 50 postmenopausal women and 25 ovulating women who served as controls. The lipoprotein estimations were repeated after 1 year of therapy with natural estrogen‐norgestrel combination. Results: More postmenopausal women than younger women had lipoprotein values in the high‐risk status (P < 0.001). There were no significant changes in lipoprotein levels (P > 0.05) after HRT. Women with a body mass index below 26 kg/m 2 had a significant reduction in their lipoprotein risk status (P < 0.01). Conclusion: There was no demonstrably clear effect of the estrogen‐progestin combination on lipoprotein levels, probably because of other compounding variables such as obesity, lack of exercise and the type of progestin used.