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Familial predisposition to uterine leiomyomas
Author(s) -
Vikhlyaeva E.M.,
Khodzhaeva Z.S.,
Fantschenko N.D.
Publication year - 1995
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(95)02533-i
Subject(s) - medicine , uterine leiomyoma , genetic predisposition , gynecology , leiomyoma , leiomyomatosis , pathology , disease
Objective: To study the clinical risk for gynecological disorders in first‐degree relatives in families with uterine leiomyoma. Method: Ninety‐seven families (215 female patients) were enrolled in this study; 97 patients and 118 of their near family relatives were examined. Results: Leiomyoma was discovered in 24.7% of cases, 2.2 times more frequently (P < 0.001) among the first‐degree female relatives in families with two or more verified leiomyoma cases. The rate of PCO disease was about 15% for both groups. Conclusion: These results confirm the concept of distinct predisposition to uterine leiomyoma and the PCO disease in first‐degree relatives in families with leiomyoma accumulation.