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Impact of maternal HIV‐1 infection on perinatal outcome
Author(s) -
Kumar R.M.,
Uduman S.A.,
Khurranna A.K.
Publication year - 1995
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(95)02356-h
Subject(s) - medicine , obstetrics , asymptomatic , pregnancy , endometritis , miscarriage , low birth weight , prospective cohort study , gynecology , genetics , biology
Objectives: To study the impact of HIV‐1 infection on pregnancy and maternal and early fetal outcome. Method: From January 1992 to January 1993, 160 HIV‐1 seropositive women and 164 HIV‐1 seronegative age‐and parity‐matched pregnant tribal women from Manipur, India, were recruited into a prospective study. Mother and infant were followed until 6 weeks postpartum. Results: Nine percent (15/160) of subjects had AIDS (CDC IV), 38% (60/160) were symptomatic (CDC III) and 53% (85/160) were asymptomatic (CDC I/II). Symptomatic (CDC III/IV) HIV‐1 infection is associated with a significantly increased rate of miscarriage, low birth weight, intrauterine fetal death and preterm delivery. Perinatal, infant and maternal deaths were limited to symptomatic women. HIV‐1 infected women were significantly younger than their HIV‐1 negative counterparts both in age and age at sexual debut. Placental membrane inflammation was significantly higher in the seropositive group and this correlated well with a higher risk of preterm delivery and postpartum endometritis. Asymptomatic HIV‐1 infection was not associated with adverse pregnancy outcome. Conclusion: Symptomatic (CDC III/IV) HIV‐1 infection in Indian tribal women is associated with adverse maternal and fetal outcome.